While the game will be won or lost by the 30 players on the pitch, the person holding the whistle does have an impact on the game.
That's why, before every Six Nations game, we will be taking a look at the man in black, or rather yellow.
The second Round 3 game sees England and Wales go head-to-head at Twickenham Stadium.
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The fierce rivals both have title ambitions but neither team can afford any further slip-ups on Saturday.
Here's who will be keeping the boys in line.
England v Wales referee: Mike Adamson
Mike Adamson is a former Scotland 7s international player.
Primarily a fly-half, he played professionally for Glasgow Warriors and London Scottish.
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Six Nations England v Wales: Full list of officials
Of course, Mike won't be on his own, with a whole team of officials acting as additional eyes and ears.
Here's the full list of referees for the England v Wales clash:
Referee: Mike Adamson (Scotland)
Assistant Referee 1: Mathieu Raynal (France)
Assistant Referee 2: Frank Murphy (Ireland)
Television Match Official (TMO): Brian MacNeice (Ireland)
The England v Wales Six Nations match takes place at Twickenham Stadium, London on Saturday, February 26 at 4.45pm.
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