One person was cut free from a vehicle by fire crews following an accident on the southbound A4072, Forge Lane, between Rogerstone and Bassaleg.
One lane of the northbound carriageway was reopened at 1pm.
The southbound carriageway remains closed as the vehicles are recovered.
A van and a Volkswagen vehicle are among the vehicles involved.
A police spokeswoman said there did not appear to be any serious injury.
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