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- Police have confirmed two people have died in the crash
- In large operation, ambulance service transported five to hospital
- Two vehicles found to have left carriageway, say police
- Serious multi-vehicle crash on M4 near Prince of Wales Police
- J22 to 21 eastbound remain closed
- 'Police-led operation' taking place
- Emergency services and traffic officers at the scene
- Heavy congestion expected through the morning
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